Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties.
نویسندگان
چکیده
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP framework is particularly tunable due to the flexible synthetic methodology. Furthermore, the central moiety has proved to be very stable to hydrolysis and reduction compared to other phenanthridinium-based agents.
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عنوان ژورنال:
- Journal of medicinal chemistry
دوره 48 14 شماره
صفحات -
تاریخ انتشار 2005